Rom J Morphol Embryol ; 59 1 : In this paper, we presented a rare case of metatypical carcinoma of the forehead with an interesting history of unexpected recurrences, underlining the clinical, therapeutic and histological essential aspects that may come in use to other clinicians in managing this type of cancer. In this case, the last recurrent tumor invaded the external layer of the frontal bone and needed a temporo-parietal flap to cover the large defect, which was previously covered in using skin grafts.
In addition to the histological aspects revealed using HE staining, in this case, diffused cancer abdominal infantil cells were p63 nuclear positive, which according papillary urothelial carcinoma patho outline Bircan et al.
The aggressive behavior was revealed by tumor's dimension, local invasion of the frontal bone with high mitotic rate as seen in the van Gieson and HE staining, also by the number of recurrences.
The prognosis of this case is reserved due to the number of recurrent tumors, immunohistochemistry anomalies, involvement of the external layer papillary urothelial carcinoma patho outline the frontal bone, tumor site, gender, poor remaining reconstructive procedures in case of a relapse, thus, close follow-up is to be recommended for a period of minimum five years.
Recurrent tumors raise treatment difficulties regarding the reconstruction procedure of the defect after wide surgical excision.
Therefore, the aggressive behavior of the MTC should be taken papillary urothelial carcinoma patho outline consideration in clinical practice.