Abstract Aim: to describe two cases of familial papillary thyroid carcinoma. Material and methods: patients were investigated by fine needle biopsy, MRI imaging and tumor biopsy, first case and histological examination of colonic and thyroid tumors first case and histological examination of thyroid tumor second case.
Results and discussion: case presentation: first case, 68 years old man had a colonic polyposis attenuated form with only a few polyps and a thyroid nodule. After hemicolectomy for a supposed colonic carcinoma with liver and lung metastases, histological examination revealed no malignant colonic disease.
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Two month later the diagnosis of invasive papillary thyroid cancer with lung metastasis prognosis tumor with lymph node metastases was made, but only an open biopsy was done because tumor invasiveness demonstrated on MTI imaging.
The biopsy identified a papillary thyroid carcinoma. Case 2: the son of the patient 30 years old without known diseases was invited to be assessed for thyroid disease.
Ultrasound examination discovered a large nodule with microcalcifications. Microscopic examination done after total thyroidectomy revealed a cribriform morular variant of papillary thyroid carcinoma, a variant that is known to be associated with FAP.
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Radioiodine ablation was made followed by suppressive thyroxine treatment. In the second case adenomatous polyposis was not found yet. In our knowledge these are the first cases of familial thyroid papillary carcinomas in our setting.
Familial history allowed an earlier diagnosis and a good management of the disease in the second case. Conclusions: according to the literature and our first experience, screening for thyroid cancer must be done in all patients with FAP and in those with a FAP helmintica significado in the family.
Nosé V. Endocr Pathol. Modern Pathology ; SS Papillary thyroid cancer with lung metastasis prognosis BM. Endocrine-Related Cancer ; Richards ML.
Thyroid ; Nilbert M, Kristoffersson U, Ericsson M, et al: Broad phenotypic spectrum in familial adenomatous polyposis; from early onset and severe phenotypes to late onset of attenuated polyposis with the first manifestation at age BMC Med Genet. Orphanet J Rare Dis ; 7. Histopathology ; Asian J Surg.
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Jpn J Cancer Res. Ito Y, Miyauchi A, Ishikawa H, et al: Our experience of treatment of cribriform morular variant of papillary thyroid carcinoma; difference in clinicopathological features of FAP-associated and sporadic patients.
Mc Donald TJ. Journal of Oncology.
A celularitate abundentă într-o metastază de tumoare neuroendocrină în tiroidă. B celule cu nucleu mărit de volum și citoplasmă foarte puţină. Cromatină nucleară cu aspect granular. C, D celule izolate, foarte discret pleomorfe, cu nuclei măriți de volum și cu aspect de tip endocrinoid al cromatinei nucleare. Metastazează preponderent pe cale hematogenă în plămânul controlateral, ficat, glande suprarenale, creier, oase, măduva osoasă [2,3].
Nasr MR. Modern Pathology. Capezzone M.