During the 6 months of therapy, 2 patients died — of non-cardiovascular reasons 3. Analysis of the safety and tolerability profile In the 6 months of therapy, 8 patients As far as the incidence of adverse reactions during the study are concerned, they were reported by the patients and recorded in the specific monitoring forms.
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The most common aspects were taken into consideration: muscular, digestive and neuropsychical disorders. No serious adverse event occurred such as hepatitis or myositis and all the reactions resolved following discontinuation of the drug therapy. The frequency of adverse events was higher in subgroup B.
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Myalgia All digestive reactions were more frequent in subgroup B and less frequent in subgroup A. Comparative presentation of adverse effects in subgroups A and B. The study group consisted of patients with CAD and with numerous associated risk factors for vascular events, while inverted papilloma urinary bladder histology pharmacological intervention with lipid-lowering therapy was prescribed for their secondary prophylaxis.
The mean level of HDL cholesterol was Also, one may note the high level of seric CRP in all patients with high common carotid inverted papilloma urinary bladder histology IMT among the studied population.
Modulation of atherosclerotic plaque burden is a new treatment target in patients with CAD. Inverted papilloma urinary bladder histology was in contrast to the low dose regimen that only prevented the progression of carotid disease. Recently, the benefit of high dose atorvastatin therapy in preventing the progression of atherosclerotic plaque in coronary arteries was explained by the favorable reduction of CRP rather than LDL cholesterol levels. Comparatively, this target was not reached in patients treated with moderate doses of statins.
The plasma lipid profile modified in a positive way in both cases, with proven superiority in patients from the group that underwent intensive therapy Our study, adjacently to other main studies on the classical therapeutic action of statins on the lipid metabolism and modulation of atherosclerosis, confirms that the high doses inverted papilloma urinary bladder histology statins exercise significantly higher anti-inflammatory effects against C-reactive protein, comparatively with the moderate dosage regimens, with complex and favorable therapeutic implications in cardiovascular patients.
The therapeutic efficacy of statins is dosedependant, regarding both the main pharmacodynamic effect on inverted papilloma urinary bladder histology plasma lipid profile and the secondary actions in reducing the atherosclerotic process by modulation of the inflammatory biological marker — seric CRP - or of the paraclinic marker — the inverted papilloma urinary bladder histology IMT. All these three parameters can be significantly modified mostly by intensive dosage regimens comparatively with the moderate dosage regimens in the patients with CAD and mixed dyslipidemia of pleiotropic etiology.
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At high doses of statin therapy, the extensive pharmacodynamic action is associated with an alteration of inverted papilloma urinary bladder histology tolerability profile in comparison with the moderate dosage regimen, and therefore it is required to rigorously follow-up the patient and the laboratory parametersafferent to the hepatic or renal deteriorations and any other side-effect occurring during the therapy.
The physician must adjust the therapeutic doses for each patient individually, taking into account the level of plasma lipid fractions and the possible presence of other chronic diseases, especially hepatic or renal disease.
The clinical study on the efficacy of statin treatment associated with the control of risk factors of atherosclerosis in CAD patients with carotid atheromatosis reveals the efficacy of statins on the reduction of the atherosclerotic risk and subsequent complications, besides the pleiotropic effects reflected in the modulation of the endothelial function, coagulation and plaque stabilization.
Intensive versus moderate lipid lowering with statins after acute coronary syndromes. Inverted papilloma urinary bladder histology Engl J Med ; Intensive lipid lowering with atorvastatin in patients with stable coronary disease.
Effect of intensive compared with moderate lipid-lowering therapy on progression of coronary atherosclerosis: a randomized controlled trial. JAMA ; Statin therapy, LDL cholesterol, C-reactive protein, and coronary disease. C-reactive protein levels and outcomes after statin therapy.
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N Engl J Med ;B. Association of coronary disease with segment specific intimal-medical thickening of the extracranial carotid artery. Circulation ; The carotid intimamedia thickness as a marker of the presence of severe symptomatic coronary artery disease.
Eur Heart J ; Carotid-artery intima and media thickness as risk factor for myocardial infarction and stroke in older adults. Intima-media thickness of the common carotid artery is the significant predictor inverted papilloma urinary bladder histology angiographically proven coronary artery disease. Can J Cardiol ; Inverted papilloma urinary bladder histology of carotid intimamedia thickness measurement and peripheral B-mode ultrasound scan in the clinical screening of patients with coronary artery disease.
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Angiology ; Carotid atherosclerosis is correlated with extent and severity of coronary artery disease evaluated by myocardial perfusion scintigraphy. Association of increased carotid media thickness with the extent of coronary artery disease.
Heart inverted papilloma urinary bladder histology Does carotid intima media thickness indicate coronary atherosclerosis? Curr Opin Cardiol ; The role of carotid arterial intima-media thickness in predicting clinical coronary events.
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Ann Intern Med ; Am J Epidemiol ; Effect of aggressive versus conventional lipid lowering on atherosclerosis progression in familial hypercholesterolemia ASAP : a prospective, randomized, doubleblind trial. Lancet Effects of lipid-lowering by simvastatin on human atherosclerosis lesions: a longitudinal study by high-resolution, noninvasive magnetic resonance imaging. Regression of carotid and femoral artery intima-media thickness in familial hypercholesterolemia: treatment with simvastatin.
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Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. Use of intravascular ultrasound to compare effects of different strategies of lipidlowering therapy on plaque volume and composition in patients with coronary artery disease. Comparison of intensive and low-dose atorvastatin therapy in the reduction of carotid intimalmedial thickness in patients with coronary heart disease.
JAMA ; 13 Statins therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. Statins, high-density lipoprotein cholesterol and regression of coronary atherosclerosis.
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Pravastatin reduces carotid intimamedia thickness progression in an asymptomatic hypercholesterolemic Mediterranean population: the Carotid Atherosclerosis Italian Ultrasound Study. Am J Med ; Rezultate: Post revascularizare miocardică, pacienţii coronarieni au prezentat un profil de risc cardiovascular marcat.
LDL colesterolul inverted papilloma urinary bladder histology scăzut semnificativ faţă de momentul iniţial, deşi la 16 luni de la revascularizare, valoarea lui absolută nu atingea recomandarea de ghid. Concluzii: La distanţă de momentul revascularizării miocardice, coronarienii rămân încă la risc cardiovascular foarte înalt.
Riscul cardiometabolic şi cel hemodinamic sunt menţinute de neatingerea valorilor ţintă conform recomandărilor ghidului de prevenţie cardiovasculară. Indicaţia, dar şi complianţa la un program structurat de recuperare cardiovasculara rămân la un nivel subliminal. Cuvinte cheie: recuperare cardiovasculară, prevenţie secundară, revascularizare miocardică. Material and methods: We evaluated the cardiovascular risk profile, the compliance to the secondary prevention measures and reaching the guidelines targets in revascularized coronary patients included in EuroAspire III Romania.
Results: After myocardial revascularization, the epidemiological risk profile of analyzed group indicated an increased frequency of cardiovascular risk factors. LDL cholesterol declined significantly from baseline, although the absolute value was far from the guidelines recommendation. Conclusion: After myocardial revascularization, coronary patients presented an increased prevalence of cardiovascular risk factors.
This high inverted inverted papilloma urinary bladder histology urinary bladder histology and hemodynamic risk was maintained due to the inability to achieve the targeted values recommended by ESC prevention guidelines. Indication as well as compliance to inverted papilloma urinary bladder histology structured cardiac rehabilitation program remains inverted papilloma urinary bladder histology a suboptimal level. Email: dimilaura gmail. Revised: Apr. Cardiovascular disease CVD is the major cause of premature death and contributes substantially to the escalating costs of healthcare.
Inverted papilloma urinary bladder histology starting date for identification was not less than 6 months and not more than 3 years prior to the expected date of interview. Patients were divided in two groups according to their participation into CRP cardiac rehabilitation program.
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We notice that biological evaluation techniques were up to the standards. Statistic analysis was performed using the Epi Info 6 version 6. Figure 1. Epidemiological risk profile. The primary lipid target, LDL cholesterol, declined significantly from baseline, but the absolute value The amount of HDL cholesterol Table 1.
Patients characteristics. Variables Baseline.