Inverted papilloma vs urothelial carcinoma

Body Weight Change Table 1 : Although transient body weight gain was observed in papilloma virus o pap test rats of the ppm dose group at the early inverted papilloma vs urothelial carcinoma of administration in male and female rats of the and ppm dose groups, both groups showed similar body weight gain with the control group.

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In male and female rats of the ppm dose group, tendency of suppression of body weight gain was observed and a significant difference was observed in comparison with the control group from Week 28 to the completion of study in male rats and from Week 8 to Week 64 in female rats. Food Consumption Table 2 : Male and female rats of each test-article dose group showed tendency of slight decrease of food consumption and significant differences were observed sporadically or frequently, inverted papilloma vs urothelial carcinoma no relationship with the dose was observed.

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Female rats of the ppm dose group exhibited significant increase during latter period of administration. Inverted papilloma vs urothelial carcinoma Efficiency Table 3 : Male and female rats of each test-article dose group showed significant increase or decrease of food efficiency in comparison with the control group during administration period, while no tendency of constant change was observed.

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Water Consumption Table 5 : Although some test-article dose group sporadically exhibited significant increase or decrease water consumption in comparison with the control group during administration period, no tendency of constant change was observed for both male and female rats of each test-article dose group. Test Article Intake Table 4 : The total test article intake during weeks were 0.

These values corresponded to 1.

Înțelesul "papilloma" în dicționarul Engleză

Result of Urinalysis Table 6 : Although there was no significant difference between each test-article dose group and the control group in the qualitative examination on each test period, all groups resulted in the increase of urine protein over time. Specific gravity decreased in male rats of the ppm dose group at 6 months and in female rats of the and ppm dose groups at 18 months, and increased in male rats of the and ppm dose groups at 24 months.

Results of Hematology Examination Table 7 : RBC decreased in male rats of the and ppm dose groups and in female rats of the ppm dose group at 12 months. Hemoglobin decreased in male rats of each test-article dose group at 12 months. Hematocrit decreased in male rats of the ppm dose groups at 12 months. Reticulocyte rate increased in female rats of the ppm dose group at 6 months and decreased in female rats of the ppm dose group at 12 months and in male rats of the ppm dose group at 18 months.

Specificații

WBC showed no difference for both male and female rats between each test-article dose group and control group on all examination period. For differential blood count, the ratio of lymphocytes increased in male rats of inverted papilloma vs urothelial carcinoma ppm dose group at 6 months and in female rats of the 30 and ppm dose groups at 12 months, the ratio of neutrophils decreased in inverted papilloma vs urothelial carcinoma rats of the ppm dose group at 6 months segmentedin female rats of the ppm dose group at 12 months stab, segmentedand in female rats of the ppm dose group at 24 months staband increased in female rats of the ppm dose group at 24 months segmented and ratio of monocytes increased in female rats of the ppm dose group at 18 months and in female rats of the 30 ppm at 24 months.

Regarding the ratios of eosinophils and of basophils, there was no difference sclerosing papilloma breast treatment male and female rats of each test-article dose group from those of the control group at all examination period. Platelet increased in female rats of the ppm dose group at 6 months and decreased in male rats of the and ppm dose groups at 12 months.

Results of Clinical Chemistry examination Table 8 : GOT increased in female rats inverted papilloma vs urothelial carcinoma the ppm dose group at 12 months and decreased in male rats of the ppm at 12 months and in male rats of the and ppm dose groups and in female rats of the ppm dose group at 18 months.

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Page 13 GPT increased in male rats of the ppm dose group at 6 months and in female rats of the ppm dose group at 12 months, and decreased in female rats of the ppm dose group at 18 months. ALP decreased in male rats of the ppm and in female rats of all the test-article dose groups at 6 months, in female rats of the and ppm dose groups at 18 months, and in female rats of the ppm dose group at 24 months, and increased in male rats of all the test-article dose groups at 12 months.

There was not observed any difference in LDH between all the test-article dose groups and the control group at all examination periods.

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Cholinesterase decreased in male rats of the ppm dose group at 6 months and in female rats of the ppm dose group at 12 months, and increased in male rats of the ppm dose group at 18 months and in female rats of the ppm dose group at 24 months.

Leucine aminopeptidase decreased in male rats of the and ppm dose groups at 6 months and increased in male rats of the inverted papilloma vs urothelial carcinoma dose group from 12 months and in female rats of all the test-article dose groups at 12 months.

Total protein decreased in male rats of the ppm dose group at 6 months. Urea nitrogen increased in male rats of the and ppm dose groups at 6 months and in female rats of all the test-article dose groups at 12 months, and decreased in female rats of the ppm dose groups at 18 months.

Creatinine decreased in female rats of the ppm dose group at 24 months. Uric acid decreased in male and female rats of the and ppm dose groups at 6 months and in male rats of the 30 ppm at 18 months.

Blood glucose level decreased in male rats of the ppm dose group at 18 months. Total cholesterol increased in male rats of all inverted papilloma vs urothelial carcinoma treatment groups at 6 months and in male rats of the ppm dose group at 18 months.

Triglyceride increased in male rats of the ppm dose group at 6 months.

Free fatty acid increased in male rats of the ppm dose group at 6 months and in male rats of the ppm dose group at 12 months. Regarding total fat, there was no difference between the test-article dose groups and the control group at all examination periods. Total bilirubin increased in male rats of inverted papilloma vs urothelial carcinoma ppm at 12 months.

Sodium increased in male rats of the ppm dose group at 6 months and decreased in female rats of the ppm dose group at 18 months and in female rats of all the test-article dose groups at 24 months.

Potassium decreased in female rats of the and ppm dose groups at 6 months and increased in male rats of the ppm dose group at 18 months and in female rats of the ppm dose group at 24 months.

Chlorine increased in male rats of the ppm at 6 months and decreased in female rats of the ppm dose group at 12 inverted papilloma vs urothelial carcinoma.

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Calcium decreased in female rats of the and ppm dose groups at 6 months and increased in male rats inverted papilloma vs urothelial carcinoma the ppm dose group at 18 months. Necropsy Findings Table 9 : At 6 and 12 months, hematoma of the pituitary, swelling of the thyroid, hypertrophy of the adrenal gland, hypertrophy and softening of the testis, nodule in the abdominal cavity, nodule and tumor mass in the subcutaneous region, and tumor mass around the nasal cavity were sporadically observed without relationship with dose.

At 18 and 24 months, hypertrophy atrophy for some animals and softening which were considered to be due to aging were observed in almost all the animals. Hematoma of the virusi fruthit gland, swelling and nodule on the thyroid, hypertrophy of the adrenal gland, nodule in the abdominal cavity, and nodule and tumor mass in the subcutaneous region were slight in severity but tended to increase over time.

In addition, neoplastic change which was thought to be attributable to aging including hypertrophy of the pituitary gland, tumor mass and nodule of the lung, tumor mass and nodule of the liver, hypertrophy and blackening of the spleen, nodule of the uterine, hypertrophy of the lymph node, ulcer of the skin were observed sporadically without relationship with dose.

In the dead animals, unspecific neoplastic change which was thought to be attributable to aging as with changes observed at 18 and 24 months.

Endpoint summary

Organ Weight Table 10 : For the brain, the absolute weight decreased in female rats of the ppm dose group at 24 months and the relative weight increased in male rats of the ppm dose group at inverted papilloma vs urothelial carcinoma and 24 months. For the pituitary gland, the relative inverted papilloma vs urothelial carcinoma increased in male rats of the ppm dose group at 6 months, and the absolute and relative weights decreased in female rats of the ppm dose group at 18 months.

Regarding the thyroid, the absolute and relative weights decreased in female rats of the ppm dose group at 6 months and in male rats of the ppm dose group at 12 months, and the absolute and relative weights increased in female rats of the ppm dose group at 12 months.

Although the thymus was not weighed at 24 months due to severe atrophy, there was no difference cancer colon prognosis the values at 6, 12, and 18 months between the control group and each test-article dose group. For the heart, the absolute weight decreased in male rats of the and ppm dose groups at 24 months.

For the lung, the absolute weight decreased in female rats of the ppm dose group at 12 months. For the liver, the absolute weight in male rats of the ppm dose group at 6 months and the relative weight in the ppm dose group increased.

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For the spleen, no difference was observed in male and female rats between all the test-article dose groups and the control group at all examination period. Regarding the kidneys, the absolute and relative weights in male rats of the and ppm at 6 months, the relative weight in female rats of the ppm dose group at 16 and 24 months, the absolute weight in male rats of the ppm dose group at 18 months, and the relative weight in male rats of the ppm dose group at 18 months anemie 8 2, and the absolute weight in female rats of the ppm dose group at 12 months decreased.

For the adrenal gland, the absolute weights decreased in female rats of the ppm dose group and male and female rats of the ppm dose group at 18 months. For the testis, the relative weights decreased in the ppm dose group at 6 months, while increase was observed in the relative weights in the ppm dose group at 12 months, and in the absolute and relative weights in all of the test groups at 24 months. For the ovary, absolute and relative weights increased in the ppm dose group at 6 month and absolute weight decreased in the ppm dose group at 12 months.

Organ Inverted papilloma vs urothelial carcinoma Table 11 : Throughout the examination periods, no accumulation of test article was observed in the liver and kidneys in all the groups.