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HUMAN PAPILLOMA VIRUS GENOTYPING IN FRESH HEAD AND NECK TUMORS - OUR FIRST EXPERIENCE
Medical research has shown a continuous increase in the incidence of skin cancers, especially among young individuals. One of the ethiopathogenic factors that cause skin carcinogenesis could be the infection with some genotypes of human papillomavirus HPV. The results were then compared with results obtained from the control group. The average α-HPV positivity in tumors was The comparative analysis between skin cancer-HPV positive Keywords: human papillomaviruses ; basal cell carcinoma ; squamous cell carcinoma ; malignant melanoma ; papilomavirusurile umane ; human papillomavirus oropharyngeal cancer bazocelular ; carcinom spinocelular ; melanom malign If the inline PDF is not rendering correctly, you can download the PDF file here.
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DOI: Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for human papillomavirus oropharyngeal cancer of sickle cell anemia. Journal of virological methods.
In addition to tobacco and alcohol abuse, certain viruses have been associated with squamous cell carcinoma SCC of the head and neck, causing alterations in DNA. It has been demonstrated that the human human papillomavirus oropharyngeal cancer HPV type 16, a subtype of the human papillomavirus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type protein RBP involved in the regulation of proliferation and cell death. Materials and method.
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Aim: To implement the HPV genotyping method of fresh head and neck cancer samples in our laboratory. More than half of the patients recognized being chronic alcohol and tobacco users. Conclusions: The genotyping method was validated according to kit instructions. To get a general idea on the prevalence of HPV genotypes in head and neck cancer in our region we tested a very small number of samples.
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According to some recent studies, the HPV infection may also increase the risk of cardiovascular diseases. Strains of HPV 16 and 18 are strains with a high cancer risk, known to cause almost all cases of cervical cancer while also increasing the risk to develop oropharyngeal cancer. Structura HPV women. Fig 1.
Dermatol Surg. Detection of mucosal type human papillomavirus in cutaneous squamous cell carcinoma in Iran. Pathol Res Pract.
Markers of cutaneous human papillomavirus infection in individuals with tumor-free skin actinic keratoses and squamous cell carcinoma.