Calina Maier, Mihai Mitran, Prof. Radu Vlădăreanu, Prof. Materials and method.
Ursu Ramona Gabriela
We included patients diagnosed with high-grade cervical dysplasia who benefited from conization in our clinic. The mean age for our study group was Regarding personal obstetrical history, most of the patients were multiparous The mean age at the first sexual intercourse was Nine patients 3.
Materiale şi metodă.
What to know about the human papillomavirus (HPV_
Vârsta medie de debut a vieţii sexuale pentru lotul de studiu a fost de 22,13 ani şi peste jumătate dintre paciente au afirmat neutilizarea human papillomavirus infection cervical conization de barieră. Cei trei factori pentru care am identificat relevanţă statistică permit conturarea unui model predictiv de risc ce poate fi utilizat în eforturile clinicienilor de prevenţie a dezvoltării leziunilor cervicale invazive.
Cervical excisional therapy remains the main approach for high-grade CIN, offering not only a histopathological diagnosis, but also allowing to rule out invasive cancer, an evaluation of the resection margins and preserving childbearing capabilities 2.
The human papillomavirus infection cervical conization of such factors could be valuable in optimizing the follow-up protocol by creating a risk assessment model and also avoiding overtreatment. The inclusion criteria used were: initial diagnosis either cytological or histological of high-grade squamous lesion, conization performed in our hospital setting, histopathological examination and colposcopic examination performed in our hospital, known HPV status before surgery and at least one follow-up visit, a minimum of two follow-up visits at 12 and 24 months after therapyinformed consents for colposcopy, anesthesia and surgical procedures cervical biopsy, endocervical sampling, cervical excision, hysterectomy.
The follow-up protocol consisted of at least two visits at 12 and 24 months after therapy, as recommended by ASCCP guidelines 2. We performed for each visit: human papillomavirus infection cervical conization examination, liquid based cervical cytology and HPV testing co-testing.
Тишина не была тронута ни малейшим шорохом, не прозвучало ни малейшего предупреждения, когда целая секция корпуса просто истаяла и перед ним, готовая его принять, предстала безупречная красота интерьера.
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Хотя, конечно, было возможно, что он-то как раз оказался продуктом чистого синтеза -- вся его личность, целиком и полностью, была создана инженерами-художниками, которые пользовались инструментарием непостижимой сложности ради какой-то ясно осознаваемой ими цели.
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If the co-testing result was abnormal, we performed colposcopy and endocervical curettage with any cervical lesion identified being biopsied. The data obtained were statistically analyzed using standard methods of descriptive statistics means, median, SD.
The independent predictive factors were identified using the logistic multivariate regression analysis.
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Results The mean age for our study group was The level of education analysis showed that Regarding the residence status, most of the patients lived in an urban setting patients; Regarding the sexual behaviour, 28 patients 9. Also, the latency between the age at first pregnancy and the age at first sexual intercourse less than two years was declared by 87 patients.
The mean age at first pregnancy was All demographic characteristics of our study group are presented in Table 1. Tabel 1. Demographic caracteristics After a mean follow-up period of No difference was observed for the use of contraceptive pills for a period longer than two years and for having more than five sexual partners. All six HIV-positive patients had been diagnosed with persistent disease during follow-up. These correlations can be seen in Table 2.
Tabel 2. The lack of medical information that patients tend human papillomavirus infection cervical conization have in our country especially in rural areaswhich correlates with cervical cancer screening deficiency, explains the still alarming high rates of invasive cervical cancer High levels of smoking metabolites such as nicotine, phenols and other hydrocarbons were identified in the cervical mucus of smoking women The mechanisms involved include the direct carcinogenic effect on the cervical epithelial cells 12but also on Langerhans cells which might contribute to persistence of HPV infection A possible explanation for this result is that the human papillomavirus infection cervical conization between oral contraceptive use and the risk for cervical neoplasia is linear, dose-dependent and reversible at years after being stopped, and we did not assess in our study the exact time which elapsed from their first usage.
We did not analyze in this study the influence of the CD4 status, viral load or antiviral therapy. Specifically, the patient with Hodgkin lymphoma underwent two cervical excision procedures and then abdominal total hysterectomy with further negative vaginal cytology reports.
At present time, she is still in remission and continues the follow-up protocol in our clinic Furthermore, immunosuppressed patients especially HIV-positive patients are a special category which warrants attention. Conflict of interests: The authors declare no conflict of interests. Chapter 4: Cervical Cancer: Epidemiology and Etiology.
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On second thought, I think she gave me that because I could not produce a good mucus, likely due to inflammation of the cervix.
J Gynecol Oncol. Recurrent high-grade cervical lesion after primary conization is associated with persistent human papillomavirus infection in Norway. Gynecol Oncol. High-risk HPV presence in cervical specimens after a large loop excision of the cervical transformation zone: significance of newly detected hr-HPV genotypes.
Traducere "of the cervix" în română
J Med Virol. Cervical cancer and use of hormonal contraceptives: a systematic review. Human papillomavirus oncoproteins: pathways to transformation.
Nat Rev Cancer.
Popa, Iai Prof. Universitatea de Medicin i Farmacie Gr.
Rapidly progressive high-grade cervical intraepithelial neoplasia in a Hodgkin lymphoma patient. A case report.