Gastric cancer metastasis

[Gastric cancer].

Abstract: Despite the significant progress regarding molecular classifications for colon, pancreatic and gastric cancer, the therapeutic methods arterial, chimio and radioembolizationthe life expectancy of patients with existing liver metastases did not improve significantly.

The aim was to analyze the interrelation between the vascularization, mast cells and the histological growth pattern of hepatic metastasis with digestive origins.

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The distribution of the liver metastasis growth pattern was as follows: colon all 3 typespancreatic replacementgastric pushing type.

A significant correlation between mast cell density in the peritumoral area and vascular microdensity in the metastatic domain of all histological growth patterns was found.

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Significant correlation between positive mast cells tryptase density and degree of differentiation for the desmoplastic type was noticed. The mast cells may have a prognostic role in this growth pattern and the mast cell inhibitor therapy may be useful.

Keywords: mast cells, liver metastasis, histological gastric cancer metastasis pattern References: 1. Histologic growth patterns gastric cancer metastasis metastatic carcinomas of the liver.


Jpn J Clin Oncol; 24—29, Liver metastases from colorectal adenocarcinomas grow in three patterns with different angiogenesis and desmoplasia. J Pathol; —, Negru Ş: Oncologie generală. Editura Victor Babeş, Capitolul 6: Invazia locală şi metastazarea, pag Mast cells, disease and gastrointestinal cancer: A comprehensive review of recent gastric cancer metastasis. Translational gastrointestinal cancer.

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Int J Mol Sci. High infiltration of mast cells positive to tryptase predicts worse outcome following resection of colorectal liver metastases.

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