Gastric cancer liver metastases

MALIGNANT TUMORS OF DIGESTIVE ORGANS AND LIVER METASTASES AT THE TIME OF DIAGNOSIS

Abstract: Despite the significant progress regarding molecular classifications for colon, pancreatic and gastric cancer, the therapeutic methods arterial, chimio and radioembolizationthe life expectancy of patients with existing liver metastases did not improve significantly. The aim gastric cancer liver metastases to analyze the interrelation between the vascularization, mast cells and the histological growth pattern of hepatic metastasis with digestive origins.

The distribution of the liver metastasis gastric cancer liver metastases pattern was as follows: colon all 3 typespancreatic replacementgastric pushing type. A significant correlation between mast cell density in the peritumoral area and vascular microdensity in the metastatic domain of all histological growth patterns was found.

Significant correlation between positive mast cells tryptase density and degree of differentiation for the desmoplastic type was noticed.

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The mast cells may have a prognostic role in this growth pattern and the mast cell inhibitor therapy may be useful. Keywords: gastric cancer liver metastases cells, liver metastasis, histological growth pattern References: 1.

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Abstract Aim: Malignant tumors localized in the digestive tract have a tendency to local growth and invasion with lymph node metastasis. Distant metastases through blood with prevalent liver location are detected late in disease progression, in an advanced stage, when therapeutic possibilities are often limited to palliative therapy. Material and methods: The study gastric cancer liver metastases a gastric cancer liver metastases of patients with liver metastases admitted to the Center of Gastroenterology and Hepatology Iasi between January 1 and October 10, for the identification of primitive tumor. The patients were investigated by endoscopy, imaging, laboratory tests including tumor markers.

Clin Exp Metastasis. A microphysiological system model of therapy for liver micrometastases. Exp Biol Med.

Several aspects of the oncological and surgical management are still controversial and so gastric cancer represents a challenge for the surgeon. This book aims to delineate the state of the art in the surgical and gastric cancer liver metastases treatment of gastric cancer, describing the new TNM staging system, the extent of visceral resection and lymphadenectomy focusing on the different open and minimally invasive surgical techniques and discussing intraoperative chemohyperthermia and neoadjuvant and adjuvant treatment.

Tumor angiogenesis in gastric cancer. Rom J Morphol Embryol. Tryptase and chymase are angiogenic in vivo in the chorioallantoic membrane assay. Int J Dev Biol.

Synovial procollagenase activation by human mast cell tryptase dependence up on matrixmetallo-proteinase 3 activation. J Clin Investig. The significant role of mast cells in cancer.

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Cancer Res. Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors. Nature Medicine, vol.

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