Blog aimed at residents in surgery URL : www. Romeo Giuli MD, resident. School of General and Emergency Surgery.
University of Gastric cancer chemotherapy. October Review Article. Primary gastric lymphoma is defined as an extranodal lymphoma arising in the stomach and is the most gastric cancer chemotherapy site of extranodal lymphoma.
PGC can spread to regional lymph nodes and become disseminated.
Metastatic gastric cancer: New targeted agents in metastatic gastric cancer
Most primary gastric lymphomas are B cell in origin although occasional cases of T-cell and Hodgkin's lymphoma are seen. Secondary gastric lymphoma indicates involvement of the stomach as a part of a diffuse lymphoma arising elsewhere.
Tertiary gastric lymphoma gastric cancer chemotherapy recurrent lymphoma involving the stomach after treatment of a nodal lymphoma and is uncommon. Staging of gastric lymphoma based upon the Ann Arbor system includes stage I E, which is disease limited to the stomach without nodal spread.
Stage II E papilloma virus 56 is tumor in the stomach with spread to gastric cancer chemotherapy contiguous lymph nodes.
Stage II Gastric cancer chemotherapy 2 is tumor in the stomach with spread to lymph nodes that are non gastric cancer chemotherapy with the primary tumor.
A major deficit gastric cancer chemotherapy the lack of a variable in the system to account for tumor grade that has been shown to be an indipendent predictor of survival 1. In the early s the concept of lymphoma gastric cancer chemotherapy mucosa associated lymphoid tissue MALT was introduced by Isaacson and Wright.
In the gastric MALT-type lymphoma, both low grade and high grade histologies are encountered, and transformation in the course of the disease is a well recognized phenomenon. However the presence of primary, diffuse, large cell lymphoma without a low grade background is not unequivocally believed to be related pathogenetically to MALT-type lymphoma.
Because the cytologic and clinical features of high grade lymphomas arising whithin a low grade background are similar to those of lesions without a low grade component, it appears reasonable to classify the latter as primary high grade MALT-type lymphomas 2.
Mucosal surfaces along the gastrointestinal tract are usually devoid of lymphatic tissue, except for specific locations, such as Peyer's patches in the ileum.
MALT is the lymphatic tissue found in the mucosa, usually acquired after inflammatory reactions or autoimmune processes, that triggers the influx of lymphocytes to the site.
The presence of MALT can be regarded as an advanced chronic inflammatory process, wich is benign by its nature. But the presence of lymphatic tissue may give rise to lymphoproliferative processes, namely lymphoma of the non-Hodgkin type.
Adrian Tase - Google Scholar Citations
It is believed that ongoing antigenic stimulation is the reason for the transformation from a benign inflammatory process to low-grade lymphoma, and subsequently, gastric cancer chemotherapy high-grade lymphoma. Over the last two decades the increasing significance of H pylri in gastric pathology has been recognized.
While it was originally found to be associated with peptic ulcer disease, it was subsequently found to play an important role in promoting other gastric pathologies: chronic gastritis, gastric MALT, MALT lymphoma and even gastric adenocarcinoma. It is not yet completely clear how H pylori triggers the gastric processes 3.
References 1 J Stephens and J Smith. Treatment of primary gastric lymphoma and gastric mucosa-associated tissue lymphoma.
J Am Coll Surg ; voln 3, Cancer ; Gastric MALT lymphoma in a Helicobacter pylori-negative patient: a case report and gastric cancer chemotherapy of the literature.
Material and methods: A retrospective study was carried out on series of patients admitted in the period June - March The duration of hospitalization was between 1 and 61 days, with an average of The data from observation files, the operating protocols, pathology reports and follow-up files were collected and analyzed. The most common complication was septic shock and mortality was 9.
J Am Coll Surg ;