Kidney Cancer Treatment Options
According to these aspects, the patient was included in the intermediate risk group, with median survival estimated at CT exam reassessment for thorax, abdomen, and pelvis with contrast substance scans are performed in Augustand then in Januaryboth suggesting stable disease. It was decided to continue the treatment with sunitinib, with the same doses, with good tolerance and no side effects. In Augustthe patient was admitted to the nephrology hospital section with elevated levels of nitrates.
Following investigations, there was no evidence of acute renal insufficiency and it was recommended to continue the sunitinib treatment. The thoracic, abdominal, pelvis CT test performed on June 18, revealed multiple numerical and dimensional secondary pulmonary lesions compared to the previous exam, a stationary aspect of adrenal lesions without other secondary lesions.
Conclusion: disease progression. Bone scintigraphy performed on July 3, revealed a scintigraphic image without oncological interest. Figure 1. Helminth therapy for ibd CT scan - November 28, Following the imaging results that highlighted the disease progression, it was decided to stop the sunitinib therapy and initiate the second-line therapy.
Figure 2. Lung CT cancer of renal lymph nodes - July 3, The thoracic, abdominal and pelvic CT test cancer of renal lymph nodes on December 4, revealed evolutionary numerical and dimensional secondary pulmonary lesions, adjacent adrenal secondary process with evolutionary aspect, mediastinal and upper abdomen cancer of renal lymph nodes lymph nodes. Between December and Octoberthe patient was treated with temsirolimus, weekly dose of 25 mg i. Figure 3. Abdominal CT scan - December 4, Thoracic, abdominal and pelvic CT exam performed on June 21, no contrast substance revealed: secondary lung lesions and left adrenal metastasis in mild dimensional progression compared to previous examination, without secondary liver and bone lesions.
Conclusion: stable disease. Figure 4. Abdominal CT scan - October 27, Bone scintigraphy on The patient continued the treatment with temsirolimus weekly with 25 mg i. Figure 5.
Abdominal CT scan - January 02, In terms of side effects cancer of renal lymph nodes temsirolimus treatment, the patient experienced repeated haematological toxicity, grade thrombocytopenia between March and Julywhich led to discontinuing the treatment and repeated platelet transfusion.
The administration is resumed hepatic cancer aflatoxin Augustafterwards — no side effects. The thoracic-abdominal-pelvic native CT scan performed on October 10th, revealed secondary lung lesions in dimensional regression from previous examination; without new lesions, the secondary lesion of the left adrenal gland in mild dimensional cancer of renal lymph nodes, but spontaneous hypodense liver lesion developed in left hepatic lobe, suspected for secondary substrate, mediastinal and infradiafragmatic adenopathies in mild dimensional regression.
Conclusion: disease progression due to new hepatic secondary lesion. Figure 6. In Cancer of renal lymph nodes chemoembolization with tandem microspheres loaded with doxorubicin mg was performed.
Between December and Januarythe patient continued temsirolimus 25 mg i.
In January 1st,a new thoraco-abdominal-pelvic CT scan was performed, which showed local right renal lobe relapse, secondary hepatic evolution dimensional and numerical tumors, hpv virus active secondary pulmonary metastases, secondary adrenal glands lesions with dimensional evolution, and cancer of renal lymph nodes osteolytic lesion vertebral body L2 - possibly secondary. It was decided to discontinue the treatment with temsirolimus, and to evaluate the following therapeutic options.
In Marchthe patient suffered a left femoral fracture by falling from his own height, for which a surgical intervention was performed on March 6th,in another clinical hospital osteosynthesis with trans-trohantero-cervico-cephalic screws.
During hospitalization, the patient had increased serum calcium levels Bone scintigraphy performed on March 20th, revealed secondary vertebral bone metastases T10, T12, Cancer of renal lymph nodesand bilateral femur metastases.
On April 12 - April 14,the patient was once again hospitalized on the nephrology section with low back pain and inferior limb pain, the diagnosis of admission being: chronic dorsolombalgia, high blood pressure grade 3, very high risk group, insulin-requiring type 2 diabetes, right nephrectomy for Gravitz tumor operated with pulmonary, right adrenal and liver metastases, asymptomatic cancer of renal lymph nodes, mixed caused hypercalcemia. In April 19th,the patient returned to the Institute of Oncology with balanced hemodynamic and respiratory status, and functional impotence in the left limb.
Biological status: anemia hemoglobin 8. Regarding continued treatment options, at the time the patient did not fit into any of the inclusion criteria according to the current therapeutic protocols, axitinib being approved in second-line therapy, and everolimus treatment was not allowed because of the low hemoglobin level and clearence to creatinine.
Also, the actual protocols do not accept the rechallenge therapy for sunitinib, and immunotherapy was not available at that time for renal carcinoma.
On April 20th,supportive treatment was human papillomavirus infection and cervical cancer erythropoietin weekly, intravenous administration, to normalize hemoglobin level, and intensive hydration to decrease creatinine levels.
Therefore, the patient started oral administration of everolimus at 10 mg dose per day. In June the patient performed external RT with palliative indication at the cancer of renal lymph nodes of bone secondary determinations and continued to administer everolimus, with good tolerance.
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Discussions What is to be cancer of renal lymph nodes is that under four targeted therapy lines, the patient showed an overall survival of 45 months after metastatic disease revealed and 49 months after the diagnosis of renal clear cell carcinoma, compared to the average survival period statistically estimated to be In order to have a correct therapeutic attitude, the following steps are essential for patients with clear kidney tumors: histological confirmation of the diagnosis, subsequently verified by immunohistochemical tests, correct staging, patient framing ranges in one of the risk groups, correct evaluation of prognostic factors, control of co-morbidities and the possibility of performing nephrectomy 3.
Regarding the treatment of systemic illness at the moment, we had several therapeutic options. According to international guidelines, in cancer of renal lymph nodes first line of treatment it cancer of renal lymph nodes preferable either to treat with tyrosine-kinase inhibitors type as sunitinib, pazopanib, axitinib for the low-risk group and intermediate risk groups, or anti-angiogenesis monoclonal papillomavirus traitement bouche bevacizumab in combination with interferon, either with first-line temsirolimus-type mTOR inhibitors for high-risk patients.
Traducere "nodulilor limfatici" în engleză
In the second line, guidelines recommend after first-line cancer of renal lymph nodes with a TKI the replacement with another TKI, or the everolimus mTOR inhibitor, or the combination of lenvatinib plus everolimus.
Also, guidelines recommend immunotherapy with nivolumab as second-line option or the new TKI cabozantinib 4. We mention that at the time, cabozantinib, lentavinib and nivolumab were not available in Romania for the treatment of metastatic renal cancer.
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According to the current therapeutic protocols, we have available in the first-line treatment of metastatic clear cell renal carcinoma the TK inhibitors sunitinib, pazopanib and monoclonal antibody anti-VEGF bevacizumab, with the mTOR inhibitor temsirolimus being reserved in the first line for patients in the high-risk group.
In the next treatment lines, axitinib and sorafenib are available as tyrosine kinase inhibitors, as well as mTOR inhibitor everolimus. All these therapies are currently available, reimbursed through the insurance system. In the correct sequencing of the treatment, a careful monitoring of the patient has an essential role.
Performing periodic determinations of imaging and laboratory investigations is imperative. At each stage of disease cancer of renal lymph nodes, he was switched to another therapeutic line, so that it was achieved a significant prolongation of survival.
Also, the control of co-morbidities through close collaboration with other specialties made it possible to continue the oncologic treatment. Maintaining the optimal dose, as well as correct sequencing of the treatment are key factors in achieving prolongation of survival to cancer of renal lymph nodes oncologic patient.
This is possible through a prompt and immediate approach to side effects of targeted therapies. It is necessary to advise the patient on adverse reactions and, where appropriate, to apply prophylactic measures.
Any grade 3 or 4 toxicity may result in dose reduction or discontinuation of the treatment, with adverse events on the subsequent disease progression 5. Conclusions With the approval of innovative molecules, the overall survival and progression-free survival have significantly improved definition papilloma virus metastatic renal carcinoma.
nodulilor limfatici - Traducere în engleză - exemple în română | Reverso Context
The control of co-morbidities through close collaboration with other specialties made it possible to continue the oncologic treatment. Recently, immunotherapy was approved in the therapeutic protocols for metastatic renal carcinoma 6. As a result, therapeutic options in metastatic renal cancer have increased over the past 10 years.
Other targeted therapies are currently under study to be approved in the future. Bibliografie 1.
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New treatment options for metastatic renal cell carcinoma. BMJ Journal.
Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma AXIS : a randomised phase 3 trial. Lancet ; —9. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med ; —