Lancet Oncol ; 20 8 :Aug. This phase trial evaluated the safety and efficacy of the hafnium oxide HfO2 nanoparticle NBTXR3 activated by radiotherapy versus radiotherapy alone as a pre-operative treatment in patients with locally advanced soft-tissue sarcoma. Sarc is a phase randomised, multicentre, international trial.
Patients had to have benign cancer stem cells WHO performance status of and a life expectancy of at least 6 months. Randomisation was stratified by histological subtype myxoid liposarcoma vs others.
This benign cancer stem cells an benign cancer stem cells study.
The primary endpoint was the proportion of patients with a pathological complete response, assessed by a central benign cancer stem cells post operation papillomavirus board following European Organisation for Research and Treatment of Cancer guidelines in the intention-to-treat population full analysis set.
Safety analyses were done in all patients who received at least one puncture and injection of NBTXR3 or at least one dose of radiotherapy. This study is registered with ClinicalTrials.
Two patients in the NBTXR3 group and one patient in the radiotherapy group were excluded from the efficacy analysis because they were subsequently discovered to be ineligible; thus, a total of patients were analysed for the primary endpoint in the intention-to-treat full analysis set 87 in the NBTXR3 group and 89 in the radiotherapy alone group.
No treatment-related deaths occurred.
The term of verrucous pigmented lesions includes a series of non-melanocytic and melanocytic, benign and malignant lesions. Among these, the most frequent is the seborrheic keratosis, a common epidermal tumor, affecting the sun exposed areas of adult. In this work we present benign cancer stem cells clinical and dermoscopical aspects of three cases of verrucous pigmented lesions two seborrheic keratoses and one seborrheic keratosis-like melanoma that determined the diagnostic algorithm as well as the therapeutic approach. The above-presented cases underline the importance of dermatoscopy to determine the malignant potential of the pigmented lesions, the final appropriate treatment being possible after the histopathologic confirmation. Dermatoscopia este o tehnică extrem de utilă în diagnosticarea leziunilor pigmentate cutaneo-mucoase, permiţând identificarea leziunilor posibil maligne.